Pair Name	Isocorydine, Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	CDH2	hsa1000
	Down-regulation	Expression	SNAI1	hsa6615
	Down-regulation	Phosphorylation	STAT3	hsa6774
	Down-regulation	Expression	TWIST1	hsa7291
	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	CFPAC-1	Cystic fibrosis	Homo sapiens (Human)	CVCL_1119
	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0480
	PaTu 8988t	Pancreatic adenocarcinoma	Homo sapiens (Human)	CVCL_1847
In Vivo Model	1×10⁷ PANC-1 cells were suspended in 100 μL of phosphate-buffered saline (PBS) and implanted subcutaneously into the right flank of each nude mouse.
Result	The synergistic treatment effect of the combination treatment of ICD and gemcitabine in pancreatic cancer cells was confirmed in established xenograft models.